TL;DR
Mounjaro is a once-weekly injectable medication that contains tirzepatide, a dual GIP and GLP-1 receptor agonist. Originally developed for Type 2 Diabetes, it has gained attention for its powerful weight loss effects. As of now, Mounjaro is not available in Singapore.
What is Mounjaro (Tirzepatide) and How Does It Work?
Mounjaro is the brand name for tirzepatide, a synthetic peptide that mimics two naturally occurring hormones: glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). These hormones help regulate blood sugar and appetite after meals.
Here’s how Mounjaro works:
- GLP-1 Receptor Activation: Encourages the pancreas to release insulin only when blood sugar levels are high, reduces the release of glucagon (which increases blood sugar), and slows gastric emptying, making you feel full longer.
- GIP Receptor Activation: Also supports insulin secretion while enhancing fat metabolism and appetite regulation.
Together, this dual action offers a more comprehensive approach to managing blood sugar and promoting weight loss than GLP-1-only medications like Ozempic.
Mounjaro has been rigorously studied in the SURPASS (for diabetes) and SURMOUNT (for weight loss) trials, showing significant improvements in weight reduction and glucose control.
What Conditions Can Mounjaro Help With?
Mounjaro is approved for:
- Type 2 Diabetes Mellitus: Helps lower blood glucose levels in adults when used along with diet and exercise.
- Chronic Weight Management: Effective in helping overweight or obese adults who have at least one weight-related condition such as hypertension, dyslipidemia, or Type 2 diabetes.
How Is Mounjaro Administered?
Mounjaro is given as a once-weekly subcutaneous injection. It is injected into the abdomen, thigh, or upper arm. It comes in a pre-filled pen that can be self-administered with proper guidance. It is essential to rotate injection sites weekly.
Are There Any Side Effects or Risks?
While Mounjaro is generally well-tolerated, possible side effects include:
- Gastrointestinal issues: Nausea, vomiting, constipation, diarrhoea, and stomach pain.
- Hypoglycemia: Especially when combined with other diabetes medications.
- Gallbladder issues: Increased risk of gallstones or cholecystitis.
- Kidney complications: Caution advised in patients with pre-existing kidney disease.
- Pancreatitis: Rare but serious. Seek help for severe abdominal pain.
- Diabetic retinopathy complications: Possible worsening in diabetic patients.
- Allergic reactions: Although rare, they can occur.
Always consult your doctor to review your medical history before starting Mounjaro.
Who Should (and Shouldn’t) Take Mounjaro?
Suitable candidates:
- Adults with Type 2 Diabetes needing better glycemic control.
- Individuals who are overweight or obese with a related condition like high blood pressure or cholesterol.
- Those ready to follow a weekly injection schedule and make lifestyle changes.
Not recommended for:
- People with a personal or family history of medullary thyroid carcinoma (MTC).
- Those with Multiple Endocrine Neoplasia Syndrome type 2 (MEN 2).
- Individuals with a history of pancreatitis.
- Pregnant or breastfeeding women.
Is Mounjaro Available in Singapore?
Currently, Mounjaro is not available in Singapore.
Individuals interested in this treatment should consult their healthcare provider to explore alternative options currently accessible in Singapore or to prepare for its potential future availability.
Final Thoughts
Mounjaro (tirzepatide) represents a new approach in medical weight loss and diabetes management. Its dual-action mechanism offers broader metabolic benefits compared to older medications. But as with any treatment, success depends on a holistic approach — healthy eating, exercise, and consistent medical support.
If you need help with losing weight, we offer weight loss coaching plans designed to help you lose weight sustainably — no crash diets, no gimmicks. Just evidence-based strategies, personalised support, and progress that lasts.
Reach out to us today and let us help you start your journey to better health.
